Close

Can’t Tolerate Retinol? Try These 6 Great Alternatives

Written by Adam Mamelak, MD, Board Certified Dermatologist on May 28, 2024 No Comments

retinol woman

Patients who are considering a change to their skin care routine have likely encountered one of today’s most popular ingredients: Retinol. Praised for its ability to combat signs of aging, acne, and uneven skin tone, retinol has become a staple in many skincare routines. However, despite its numerous benefits, retinol is not always the best fit for everyone. But, for those with sensitive skin or who simply cannot tolerate retinol, there are plenty of effective alternatives that provide similar benefits without the irritation.

What Is Retinol?

Retinol, a derivative of vitamin A, is a potent ingredient known for its ability to increase cell turnover, stimulate collagen production, and unclog pores. It is widely regarded as one of the most effective anti-aging ingredients available over the counter.

Your late 20’s or early 30’s is ideal and often the time I recommend patients start incorporating a Retinol into their skin care regimen. These are the times when our skin begins showing early signs of aging and photodamage, and when we begin to focus on preserving skin health and a youthful appearance.

Valued for its ability to promote skin renewal and rejuvenation, when applied topically, retinol penetrates the skin and interacts with specific receptors, ultimately influencing gene expression and cellular processes. One of the primary mechanisms of action is its stimulation of collagen production and enhancement of cell turnover.

The Various Benefits of Retinol for Skincare

From reducing the appearance of fine lines and wrinkles to fading dark spots and acne scars, retinol is a multitasking powerhouse. Overall, retinol is prized for its multifaceted benefits in skincare, including:

  • Anti-aging: By stimulating collagen production and promoting cell turnover, retinol helps reduce the appearance of wrinkles, fine lines, and sagging skin.
  • Skin renewal: Retinol enhances skin texture, evens out skin tone, and improves overall skin radiance by encouraging the shedding of dead skin cells and the generation of new ones.
  • Acne treatment: Retinol can help unclog pores, reduce inflammation, and prevent acne breakouts, making it an effective treatment for acne-prone skin. Retinol is now considered a first line treatment for acne by many dermatologists and skincare experts.

Drawbacks of Retinol

While retinol offers remarkable benefits, it is not without its drawbacks, especially for those with sensitive skin.

  • Skin irritation: One of the most common side effects of retinol is skin irritation. It can cause redness, flakiness, and peeling, particularly when first introduced to a skincare routine or when used in high concentrations. I often advise patients to use a retinol twice a week initially, or in conjunction with a moisturizer to help decrease these effects.
  • Increased sensitivity to sun: Retinol can make the skin more sensitive to sunlight, increasing the risk of sunburn and damage. This makes it less than ideal for individuals who spend a lot of time outdoors or have sun-sensitive skin. It’s also one of the primary reasons many of these preparations are for nighttime application.
  • Not well-tolerated by some: Even in lower concentrations, retinol may not be tolerated well by individuals with sensitive skin, leading to persistent irritation and discomfort.
  • Pregnancy and breastfeeding concerns: Due to its potential to cause birth defects, retinol is not recommended for use during pregnancy or breastfeeding. Pregnant or breastfeeding individuals should consult with their healthcare provider before using retinol or any retinoid-containing products.

Try These Retinol Alternatives

Fortunately, there are several alternatives to retinol that offer similar benefits without the unwanted side effects. If you have tried retinol but found it to be too harsh here are 6 great alternatives:

1. Bakuchiol

Derived from the seeds of the babchi plant, bakuchiol has gained popularity as a natural alternative to retinol. With the rise and popularity of clean skincare, Bakuchiol has become a go to for many of my patients looking for a retinol alternative. It functions similarly to retinol by stimulating collagen production and promoting cell turnover but without the associated irritation. Bakuchiol is gentle on the skin, making it suitable for sensitive skin types. Look for it in serums and moisturizers for daily use.

2. Alpha Hydroxy Acids (AHAs)

AHAs, such as glycolic acid and lactic acid, are chemical exfoliants that work by dissolving the bonds between dead skin cells, revealing smoother, brighter skin underneath. They help improve skin texture, fade dark spots, and reduce the appearance of fine lines and wrinkles. AHAs are less irritating than retinol and can be found in cleansers, toners, and serums.

3. Peptides

Peptides are short chains of amino acids that help boost collagen production and improve skin elasticity. They can help reduce the appearance of wrinkles and fine lines while hydrating and firming the skin. Peptides are gentle and suitable for all skin types, making them an excellent alternative to retinol. Look for them in serums and moisturizers.

4. Vitamin C

Vitamin C is a powerful antioxidant that helps brighten the skin, fade dark spots, and protect against environmental damage. It promotes collagen synthesis and enhances skin radiance. Vitamin C is well-tolerated by most skin types and can be found in serums and creams.

5. Glutathione

Glutathione is a potent antioxidant that helps neutralize free radicals and brighten the skin. It can help reduce hyperpigmentation, improve skin tone, and promote a more even complexion. Glutathione is gentle on the skin and suitable for all skin types.

6. Niacinamide (Vitamin B3)

Niacinamide is a versatile ingredient that helps regulate oil production, minimize pores, and strengthen the skin barrier. It can improve uneven skin tone, reduce redness, and soothe inflammation. Niacinamide is non-irritating and well-tolerated by sensitive skin.

While retinol offers impressive benefits for skincare, it is not the only option available. If you find retinol too harsh or irritating for your skin, consider trying one of these alternatives. Whether you opt for bakuchiol, AHAs, peptides, vitamin C, glutathione, or niacinamide, you can still achieve radiant, youthful-looking skin without the potential unwanted side effects of retinol products.


Adam Mamelak, MD

Adam Mamelak, MD is an American and Canadian Board Certified Dermatologist and an American Board Certified, Fellowship-Trained Mohs Micrographic Surgeon at Westlake Dermatology. Dr. Mamelak obtained his Bachelor degree and graduated in the top 5% of the Faculty of Science from McGill University, and was a gold medalist (the highest honor obtainable) in his medical class at Queen’s University. He completed his Dermatology residency training at The Johns Hopkins University, where he also completed a research fellowship in Molecular Immunology. Dr. Mamelak completed fellowship training in Mohs Surgery/Procedural Dermatology at the Methodist Hospital in Houston.


Leave a Reply